The Johannesburg side will want to improve on a home record which has seen them claim 12 points from a possible 24.
The Clever Boys are placed eighth on the Absa Premiership log with 18 points from 15 matches.
Stars recorded a third win from their last four league matches when they defeated Black Leopards 2-1 away from home on the weekend.
The Free State side has a decent away record so far this season, with 11 points claimed from a possible 21.
Ea Lla Koto are placed fourth on the Absa Premiership log with 24 points from 15 matches.
In head-to-head stats, Wits and Stars have met in 44 league matches since 1986.
The Clever Boys have claimed 15 wins compared to 12 for Ea Lla Koto, while 17 matches have ended in draws.
Wits have a good home record against Star down the years, with 11 wins, eight draws and just two losses from 21 matches.
When the teams met earlier this season, Ea Lla Koto claimed a 2-0 home win thanks to goals from Masehe and Chivuta.
Wits’ line-up from their 2-0 loss to Sundowns: Harrison, Gumede, Sweswe, Mayinga (Mashaba 46’), Seedat, Pattison (Fanteni 87’), Nengomasha, Vilakazi, Nato, Chapman (Jayiya 70’), Kadi.
Stars’ line-up from their 2-1 win over Leopards: Mweene (Motsoeneng 72’), Mkwanazi, Cardoso, Ouro-Akoriko, Wiltwer, Nomandela, Esterhuizen, Kerspuy (Coetzee 70’), Masehe, Wome, Mvula (Mkhatshwa 62’).