Celtic come into the game looking to turn around their form, having been beaten 2-0 away by Platinum Stars in midweek.
The Bloemfontein side has a pretty good record at home this season, with five wins from eight matches.
Phunya Sele Sele are placed eighth on the Absa Premiership log with 21 points from 17 matches.
Wits got 2013 off to a great start with their first win since November last year, as they defeated Black Leopards 2-0 away on Tuesday.
The Johannesburg side will be looking to improve further on an away record which has seen them claim two wins from nine matches on the road this season.
The Clever Boys are placed seventh on the Absa Premiership log with 22 points from 17 matches.
In head-to-head stats, Celtic and Wits have met in 47 league matches since 1985.
The Clever Boys have claimed 19 wins, while the remaining 28 matches are split evenly between Phunya Sele Sele wins and draws.
Celtic have a good home record against the Johannesburg team, with 10 wins, seven draws and five losses from 22 matches down the years.