AmaZulu ended a winless streak of three matches with a 1-0 victory at home to Bloemfontein Celtic in midweek.
The Durban side has recorded four wins, five draws and three losses from 12 home matches so far this season.
Usuthu are placed 13th on the Absa Premiership log with 28 points from 25 matches.
Sundowns are unbeaten in their last three league matches, but were held to a 1-1 home draw by University of Pretoria in midweek.
The Tshwane side has recorded just three wins from 12 away matches this season, suffering four defeats in the process.
The Brazilians are placed 11th on the Absa Premiership log with 28 points from 24 matches.
In head-to-head stats, AmaZulu and Sundowns have met in 48 league matches since 1985.
The Brazilians have claimed 31 wins compared to just six for Usuthu, while 11 matches have been drawn.
AmaZulu have won just two of their 24 home matches against the Tshwane side down the years. They last beat ‘Downs at home in the 1993 season.
When the teams met earlier this season in Gauteng, they played to a 1-1 draw with goals from Laffor and Khumalo for the home and away side respectively.