AmaZulu suffered a second successive away defeat when they went down 2-1 at Free State Stars on the weekend.
The Durban side has recorded four wins, six draws and three defeats from their 13 home matches so far this season.
Usuthu are placed 12th on the Absa Premiership log with 29 points from 27 matches.
Leopards suffered a fourth loss from their last five league matches when they were beaten 3-1 at home by University of Pretoria on the weekend.
The Limpopo side has recorded just two wins away from home this season, suffering six defeats from 12 matches in the process.
Lidoda Duvha are placed 15th on the Absa Premiership log with 23 points from 26 matches.
In head-to-head stats, AmaZulu and Leopards have met in 11 league matches since 2001/02.
Both sides have claimed five wins against the other, while there has been just one draw.
AmaZulu have won three of their five home matches against Leopards, suffering two defeats in the process.
When the teams met earlier this season in the Limpopo province, they played out a 1-1 draw.