SuperSport suffered their biggest defeat of the season last time out, going down 3-0 away to Platinum Stars.
The Pretoria team has picked up seven points from a possible 12 in their four home matches so far this season.
Their next three league opponents are Ajax Cape Town (home), Bidvest Wits (away) and Mamelodi Sundowns (home).
Matsatsantsa are placed fourth on the Absa Premiership log with 15 points from nine matches.
Arrows scored just their second league win of the season in midweek, taking down high-flying Moroka Swallows 2-1 at home.
The Durban side has recorded one win and three defeats from their four matches on the road this season.
Their next three league opponents are Maritzburg United (home), Bloemfontein Celtic (away) and Platinum Stars (home).
Abafana Bes’thende are placed 15th on the Absa Premiership log with seven points from eight matches.
In head-to-head stats, SuperSport and Arrows have met in 26 league matches since 2000/01.
United have claimed 14 wins compared to seven for Abafana Bes’thende, while just five matches have ended in draws.
SuperSport have a strong home record against Arrows, with seven wins and just three defeats from 13 matches.
Last season Matsatsantsa took four points off their Durban counterparts, drawing 2-2 in Gauteng before a 1-0 win in the return match in KwaZulu-Natal.