The Hammers host Man United, live on Sky Sports, in their final home game before making the move to the Olympic Stadium next season and emotions are bound to be high among the Boleyn faithful.
But the game is just as important for Van Gaal’s side, who know they can move ahead of rivals Manchester City into fourth place with victory in the East End of London.
That would leave them needing only to beat Bournemouth on the final day of the Premier League season to ensure Champions League football for themselves and a place in the Europa League for City.
Man United have already spoiled one big Boleyn Ground night for West Ham when they knocked them out of the FA Cup in a sixth-round replay last month.
Asked if United can use the emotion of the night against West Ham, Van Gaal said: “Yes it is a big night. I think the players shall feel that also.
“Tuesday we have to play against an opponent who says goodbye to the stadium. So they won’t want to lose in their own stadium.
“They have already lost to Man United in the FA Cup match. That is also history. That is not good for us. And West Ham United is a very good team.