Reigning champions SuperSport United welcome Bloemfontein Celtic FC in the first leg semifinal of the MTN8 Cup.
The two sides are scheduled to play at Lucas Moripe Stadium on Sunday afternoon.
Kickoff is at 15:00.
Matsatsantsa are looking to regain their confidence after losing to Golden Arrows FC in a midweek encounter in the KwaZulu-Natal province.
In the quarterfinal, Matsatsantsa eliminated rookies TTM FC in the Limpopo province a fortnight ago.
This is going to be a tough one as the meeting between the two sides is not easily predictable.
Matsatsantsa will rely on players such as forward Bradley Grobler, skipper Ronwen Williams, veteran Clayton Daniels, midfielder Teboho Mokoena and new striker Iqraam Rayners.
This is also another exciting opportunity for the Matsatsantsa supporters to watch some of their new signings.
In the quarterfinal, Rayners registered his maiden strike in the United colours.
The match will be televised live on SuperSport channel 202.