AmaZulu will travel to the Dr Molemela Stadium where they are scheduled to face Bloemfontein Celtic on Sunday.
Kick-off is at 15h30 CAT.
Usuthu were last in action on December 20, defeating Chippa United 3-1 in an encounter which was played at the Jonsson Kings Park Stadium.
Augustine Mulenga scored his first-ever goal for AmaZulu, while Luvoyo Memela continued his scoring form by grabbing a brace.
AmaZulu have claimed just one point from three away matches this season, with their last result on the road a 1-1 draw at Tshakhuma Tsha Madzivhandila in early December.
Meanwhile, Celtic suffered a fourth league loss when they were beaten 2-1 by Maritzburg United in a game which took place at Harry Gwala Stadium on January 2.
Phunya Sele Sele, who scored through Victor Letsoalo, became the first team to lose to the Team of Choice this season.
Celtic have claimed seven points from four home matches this season, with their last result as hosts a 2-0 win over Baroka FC on December 16.
In head-to-head stats, AmaZulu and Celtic have met in 54 league matches since 1985.
Phunya Sele Sele have claimed 20 wins compared to 14 for Usuthu, while 20 matches have been drawn.
The Bloemfontein side has won 14 of their 28 home league matches against the Durban club, suffering three defeats in the process.
AmaZulu took four points off Celtic in the teams’ league meetings last season.
A 2-1 win for Usuthu at the Dr Molemela Stadium in December 2019 was followed by a 2-2 draw in the return game at the Lucas Moripe Stadium in August 2020.